Identification of (3R)-7-hydroxy-N-((1S)-1-{[(3R, 4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidiny l]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide as a novel potent and selective opioid K receptor antagonistTHOMAS, James B; ATKINSON, Robert N; CANTRELL, Buddy E et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 14, pp 3127-3137, issn 0022-2623, 11 p.Article

Identification of the first trans-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid k receptor antagonist activityTHOMAS, James B; ATKINSON, Robert N; ZIMMERMAN, Dennis M et al.Journal of medicinal chemistry (Print). 2001, Vol 44, Num 17, pp 2687-2690, issn 0022-2623Article

Importance of phenolic address groups in opioid kappa receptor selective antagonistsTHOMAS, James B; FIX, Scott E; ROTHMAN, Richard B et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 4, pp 1070-1073, issn 0022-2623, 4 p.Article

Discovery of an opioid κK receptor selective pure antagonist from a library of N-substituted 4β-methyl-5-(3-hydroxyphenyl)morphansTHOMAS, James B; ATKINSON, Robert N; DERSCH, Christina M et al.Journal of medicinal chemistry (Print). 2002, Vol 45, Num 16, pp 3524-3530, issn 0022-2623Article

The Effect of κ-Opioid Receptor Agonists on Tetrodotoxin-Resistant Sodium Channels in Primary Sensory NeuronsXIN SU; CASTLE, Neil A; ANTONIO, Brett et al.Anesthesia and analgesia. 2009, Vol 109, Num 2, pp 632-640, issn 0003-2999, 9 p.Article

Highly potent and selective phenylmorphan-based inverse agonists of the opioid δ receptorTHOMAS, James B; LI ZHANG; NAVARRO, Hernan A et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 18, pp 5597-5609, issn 0022-2623, 13 p.Article

Discovery of the first N-substituted 4β-methyl-5-(3-hydroxyphenyl)morphan to possess highly potent and selective opioid 6 receptor antagonist activityCARROLL, F. Ivy; LI ZHANG; MASCARELLA, T. S et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 2, pp 281-284, issn 0022-2623, 4 p.Article

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na_v1.8 sodium channel with efficacy in a model of neuropathic painSCANIO, Marc J. C; LEI SHI; YI LIU et al.Bioorganic & medicinal chemistry. 2010, Vol 18, Num 22, pp 7816-7825, issn 0968-0896, 10 p.Article

Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activitiesTHOMAS, Brian F; FRANCISCO, Ma. Elena Y; SELTZMAN, Herbert H et al.Bioorganic & medicinal chemistry. 2005, Vol 13, Num 18, pp 5463-5474, issn 0968-0896, 12 p.Article

N-substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines are opioid receptor pure antagonistsCARROLL, F. Ivy; CHAUDHARI, Sachin; THOMAS, James B et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 26, pp 8182-8193, issn 0022-2623, 12 p.Article

A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assaySMITH, Emilie D; ARIANE VINSON, N; DESONG ZHONG et al.Bioorganic & medicinal chemistry. 2008, Vol 16, Num 2, pp 822-829, issn 0968-0896, 8 p.Article

Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic painDRIZIN, Irene; GREGG, Robert J; CHAPMAN, Mark L et al.Bioorganic & medicinal chemistry. 2008, Vol 16, Num 12, pp 6379-6386, issn 0968-0896, 8 p.Article

Factors influencing agonist potency and selectivity for the opioid δ receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N, N-diethylbenzamidesTHOMAS, James B; HERAULT, Xavier M; CARROLL, F. Ivy et al.Journal of medicinal chemistry (Print). 2001, Vol 44, Num 6, pp 972-987, issn 0022-2623Article

Subtype-selective Na_v1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivativesKORT, Michael E; ATKINSON, Robert N; MATULENKO, Mark A et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 22, pp 6812-6815, issn 0960-894X, 4 p.Article

Synthesis and In Vitro Opioid Receptor Functional Antagonism of Methyl-Substituted Analogues of (3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic)PABLO CUEVA, Juan; BILL CAI, Tingwei; WAYNE MASCARELLA, S et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 23, pp 7463-7472, issn 0022-2623, 10 p.Article

Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Na_v1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory PainKORT, Michael E; DRIZIN, Irene; CARROLL, William A et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 3, pp 407-416, issn 0022-2623, 10 p.Article

Synthesis and In Vitro Opioid Receptor Functional Antagonism of Analogues of the Selective Kappa Opioid Receptor Antagonist (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic)CAI, Tingwei Bill; ZHOU ZOU; THOMAS, James B et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 6, pp 1849-1860, issn 0022-2623, 12 p.Article

Pharmacological properties of JDTic: a novel κ-opioid receptor antagonistCARROLL, Ivy; THOMAS, James B; DYKSTRA, Linda A et al.European journal of pharmacology. 2004, Vol 501, Num 1-3, pp 111-119, issn 0014-2999, 9 p.Article